Advocacy and support resources

You are not alone

Finding help is easier than you may think. A diagnosis like this can feel isolating. But there are communities of people who understand and can relate to what you are going through and are ready to support you.

You are not alone

Debbie's Dream Foundation

Debbie's Dream Foundation is a national nonprofit dedicated to supporting patients and families affected by stomach cancer through cooking demonstrations, mentoring, and other programs to make sure that nobody has to face stomach cancer alone.

debbiesdream.org

Gastric Cancer Foundation

The Gastric Cancer Foundation has videos and other tools help you with everyday holistic physical and emotional needs, including a series of cooking videos hosted by a chef who is a stomach cancer survivor.

gastriccancer.org

The GI Cancers Alliance

The GI Cancers Alliance offers patient navigators to provide personalized guidance and support to patients and families across all gastrointestinal cancer types. This program helps better understand their diagnosis, explore treatment options, and access appropriate testing and clinical trials.

gicancersalliance.org

Hope for Stomach Cancer

Hope for Stomach Cancer is a national nonprofit dedicated to connecting and supporting individuals affected by stomach cancer. They provide nutrition education, community support, and direct access to medical experts so patients and caregivers never have to navigate this disease alone.

stocan.org

CancerCare

For over 80 years, CancerCare has empowered millions of people affected by cancer through free counseling, resource navigation, support groups, educational resources, advocacy, and direct financial assistance.

cancercare.org

Jazz Pharmaceuticals does not own, manage, or control any third-party organizations that may be mentioned or linked, and Jazz Pharmaceuticals does not endorse or guarantee the actions, content, or services of any third party. Patients should discuss any questions or decisions regarding care with their healthcare provider.

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What is ZIIHERA?

ZIIHERA (zanidatamab-hrii) 50 mg/mL is a prescription medicine used to treat adults with gastroesophageal cancer (GEA) including gastric cancer, esophageal cancer, and gastroesophageal junction (GEJ) cancer. ZIIHERA is used in combination with fluoropyrimidine- and platinum-containing chemotherapy with or without tislelizumab-jsgr as the first treatment when your GEA:

cannot be removed by surgery or has spread to other parts of your body (metastatic); and
your tumor tests positive for human epidermal growth factor receptor 2 (HER2 IHC 3+ or IHC 2+/ISH+).

Your healthcare provider will perform a test to make sure ZIIHERA is right for you.

It is not known if ZIIHERA is safe and effective in children.

IMPORTANT SAFETY INFORMATION

ZIIHERA can cause serious side effects, including:

Diarrhea. Diarrhea during treatment with ZIIHERA can be severe, life threatening, and can lead to death. Diarrhea may cause loss of fluids and body salts (electrolytes). To help prevent or reduce diarrhea during treatment with ZIIHERA, your healthcare provider:
- will tell you to drink more fluids.
- start you on an antidiarrheal medicine such as loperamide or other treatment, as needed.
- may temporarily stop, reduce your dose or permanently stop treatment with ZIIHERA, or other medicines you take.

If you get new or worsening diarrhea, tell your healthcare provider right away and take antidiarrheal medicine as prescribed. Follow all of your healthcare providers instructions to help with your diarrhea.

Harm to your unborn baby. Taking ZIIHERA during pregnancy or within 4 months before pregnancy can harm your unborn baby. Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with ZIIHERA.

Females who are able to become pregnant:

Your healthcare provider should do a pregnancy test before you start treatment with ZIIHERA.
Use effective birth control (contraception) during treatment with ZIIHERA and for 4 months after the last dose.

Heart problems that may affect how well your heart pumps blood. Your healthcare provider will check your heart function before and during treatment with ZIIHERA. Tell your healthcare provider right away if you get any of the following signs and symptoms of a heart problem:
- new or worsening shortness of breath
- feeling more tired than usual
- swelling of your ankles or feet
- loss of consciousness
- irregular heartbeat
- sudden weight gain
- dizziness or feeling light-headed
Infusion-related reactions. Your healthcare provider will check for side effects during your infusions. Tell your healthcare provider right away if you get any of the following symptoms during or after your infusions of ZIIHERA:
- shortness of breath or trouble breathing
- fever
- chills
- rash
- flushing
- nausea or vomiting
- dizziness or feeling light-headed
- chest discomfort

Before receiving ZIIHERA, tell your healthcare provider about all of your medical conditions, including if you:

have or have had any heart problems.
are breastfeeding or plan to breastfeed. It is not known if ZIIHERA passes into your breastmilk. Talk to your healthcare provider about the best way to feed your baby if you receive treatment with ZIIHERA.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Other common side effects when ZIIHERA is given in combination with chemotherapy and tislelizumab-jsgr include:

diarrhea
nausea
decreased appetite
low levels of blood potassium
vomiting

feeling tired
numbness, pain, tingling, or burning in your hands or feet
rash
infusion-related reactions

Other common side effects when ZIIHERA is given in combination with chemotherapy include:

diarrhea
nausea
vomiting
numbness, pain, tingling, or burning in your hands or feet
decreased appetite

feeling tired
low levels of blood potassium
infusion-related reactions
rash

These are not all the possible side effects of ZIIHERA. Call your doctor for medical advice about side effects.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch

Please see the full Prescribing Information, including BOXED WARNINGS and Medication Guide, and discuss with your doctor.